Mobility is central to quality of life. It empowers people to move freely, maintain posture, and navigate daily life with confidence. And it matters at every age.

While mobility was once viewed solely as a concern for seniors, proprietary research commissioned by Everwell Health reveals that people of all ages are interested in keeping their bodies moving, whether Gen Z seeking to maintain physical fitness, Millennials juggling family activities and daily demands, Gen Xers working to preserve joint and muscle function, or Boomers protecting their ability to live independently.¹

Cetylated fatty acids (CFAs), formed when fatty acids are combined with cetyl alcohol, support mobility by promoting joint comfort and ease of movement. What makes them stand out is their bioavailability. CFAs are readily absorbed, allowing them to reach tissues and joints—right where they have a strong impact.

What is Celadrin®?

Celadrin is a proprietary combination of CFAs clinically shown to support multiple aspects of joint health. In human clinical trials, Celadrin has significantly improved joint function and mobility in as little as one week.

How Does Celadrin Work?

The CFAs in Celadrin work through a triple-level cellular action with three distinct mechanisms. 

1. Supports a healthy inflammation response²
2. Promotes the formation of chondrocytes (cells that build joint cartilage)²
3. Integrates into cell membranes to support fluidity and function²

The Research Backing Celadrin®

Celadrin is supported by decades of scientific research on CFAs, demonstrating beneficial effects both orally and topically.

Two placebo-controlled human clinical trials illustrate Celadrin’s impact on knee function and walking distance when taken orally. One study of 64 individuals with knee discomfort, published in the Journal of Rheumatology, found Celadrin increased knee range of motion and overall knee function after 68 days.³ A second trial showed Celadrin improved joint comfort and increased six-minute walking distance by over 500 feet — more than a football field — among 93 participants over the course of eight weeks.⁴

In practical terms, these findings translate to freer, easier movement in day-to-day life. With better knee function and the ability to move quicker, consumers can keep doing what they love longer, whether that’s playing pickleball, taking their favorite hike, or running a 5K.

Topical use of Celadrin has also demonstrated benefits in published research. A cream combining Celadrin and menthol improved stair-climbing ability, “up and go” performance, balance and strength, range of motion, and joint comfort after just one week among people with knee, elbow, or wrist discomfort.⁵ Notably, the percentage improvements were consistent with the researchers’ prior findings on a CFA formulation without menthol, suggesting the benefits are derived from the CFAs themselves.

Additional research on both oral and topical administration of CFAs shows improvements in joint comfort^6–9 and balance while standing.¹⁰

Dual-Formulation Flexibility

Available in both powder and oil formats, plant-derived Celadrin® can be included in oral or topical formulations, offering flexibility for formulators and convenience for consumers.

Whether working from the inside out or the outside in, Celadrin® supports full-spectrum mobility.

Click here to learn more about the triple-level cellular action of Celadrin® plant-derived CFAs.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

References

1. Everwell Health. Healthy Aging Proprietary Consumer Research. Published online 2025.
2. Hudita A, Galateanu B, Dinescu S, et al. Cartilage. 2020;11(1):88-97. doi:10.1177/1947603518775798
3. Hesslink R, Armstrong D, Nagendran MV, Sreevatsan S, Barathur R. J Rheumatol. 2002;29(8):1708-1712.
4. Udani JK, Singh B, Torreliza M, Crabtree M, Zhang G. Presented at: Scripps Integrated Medical Conference. 2011.
5. Kraemer WJ, Ratamess NA, Maresh CM, et al. J Strength Cond Res. 2005;19(2):475-480. doi:10.1519/R-505059.1
6. Ariani A, Parisi S, Guidelli GM, Bardelli M, Bertini A, Fusaro E. Arch Rheumatol. 2018;33(4):438-442. doi:10.5606/ArchRheumatol.2018.6711
7. Suwannaphisit S, Sinnathakorn N, Suwanno P, Fongsri W, Tangtrakulwanich B. Sci Rep. 2025;15(1):4587. doi:10.1038/s41598-025-88202-1
8. Zodeleva M, Pochkhua N, Rossato MS, Arziani E. Eur J Clin Nutr. 2025;79(11):1138-1143. doi:10.1038/s41430-025-01656-4
9. Lee SC, Jin HS, Joo Y, Kim YC, Moon JY. Medicine (Baltimore). 2017;96(9):e6149. doi:10.1097/MD.0000000000006149
10. Kraemer WJ, Ratamess NA, Maresh CM, et al. J Strength Cond Res. 2005;19(1):115-121. doi:10.1519/5050504.1